Publications

Lukowski, A. L., Hubert, F. M., Ngo, T.-E., Avalon, N. E., Gerwick, W. H., & Moore, B. S. (2023). Enzymatic Halogenation of Terminal Alkynes. Journal of the American Chemical Society, 145(34), 18716–18721. https://doi.org/10.1021/jacs.3c05750
Zetzsche, L. E., Yazarians, J. A., Chakrabarty, S., Hinze, M. E., Murray, L. A. M., Lukowski, A. L., Joyce, L. A., & Narayan, A. R. H. (2022). Biocatalytic oxidative cross-coupling reactions for biaryl bond formation. Nature, 603(7899), 79–85. https://doi.org/10.1038/s41586-021-04365-7
Purdy, T. N., Moore, B. S., & Lukowski, A. L. (2022). Harnessing ortho-Quinone Methides in Natural Product Biosynthesis and Biocatalysis. Journal of Natural Products, 85(3), 688–701. https://doi.org/10.1021/acs.jnatprod.1c01026
Adak, S., Lukowski, A. L., Schafer, R. J. B., & Moore, B. S. (2022). From tryptophan to toxin: Nature’s convergent biosynthetic strategy to aetokthonotoxin. Journal of the American Chemical Society, 144(7), 2861–2866. https://doi.org/10.1021/jacs.1c12778
Liu, J., Tian, J., Perry, C., Lukowski, A. L., Doukov, T. I., Narayan, A. R. H., & Bridwell-Rabb, J. (2022). Design principles for site-selective hydroxylation by a Rieske oxygenase. Nature Communications, 13(1), 255. https://doi.org/10.1038/s41467-021-27822-3
Lukowski, A. L., Liu, J., Bridwell-Rabb, J., & Narayan, A. R. H. (2020). Structural basis for divergent C–H hydroxylation selectivity in two Rieske oxygenases. Nature Communications, 11(1), 2991. https://doi.org/10.1038/s41467-020-16729-0
Lukowski, A. L., Mallik, L., Hinze, M. E., Carlson, B. M., Ellinwood, D. C., Pyser, J. B., Koutmos, M., & Narayan, A. R. H. (2020). Substrate Promiscuity of a Paralytic Shellfish Toxin Amidinotransferase. ACS Chemical Biology, 15(3), 626–631. https://doi.org/10.1021/acschembio.9b00964
Denomme, N., Lukowski, A. L., Hull, J. M., Jameson, M. B., Bouza, A. A., Narayan, A. R. H., & Isom, L. L. (2020). The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6. Neuroscience Letters, 724, 134853. https://doi.org/10.1016/j.neulet.2020.134853
Lukowski, A. L., Denomme, N., Hinze, M. E., Hall, S., Isom, L. L., & Narayan, A. R. H. (2019). Biocatalytic Detoxification of Paralytic Shellfish Toxins. ACS Chemical Biology, 14(5), 941–948. https://doi.org/10.1021/acschembio.9b00123
Lukowski, A. L., & Narayan, A. R. H. (2019). Natural Voltage‐Gated Sodium Channel Ligands: Biosynthesis and Biology. ChemBioChem, 20(10), 1231–1241. https://doi.org/10.1002/cbic.201800754
Rodríguez Benítez, A., Tweedy, S. E., Baker Dockrey, S. A., Lukowski, A. L., Wymore, T., Khare, D., Brooks, C. L., Palfey, B. A., Smith, J. L., & Narayan, A. R. H. (2019). Structural Basis for Selectivity in Flavin-Dependent Monooxygenase-Catalyzed Oxidative Dearomatization. ACS Catalysis, 9(4), 3633–3640. https://doi.org/10.1021/acscatal.8b04575
Lukowski, A. L., Ellinwood, D. C., Hinze, M. E., DeLuca, R. J., Du Bois, J., Hall, S., & Narayan, A. R. H. (2018). C–H Hydroxylation in Paralytic Shellfish Toxin Biosynthesis. Journal of the American Chemical Society, 140(37), 11863–11869. https://doi.org/10.1021/jacs.8b08901
Baker Dockrey, S. A., Lukowski, A. L., Becker, M. R., & Narayan, A. R. H. (2018). Biocatalytic site- and enantioselective oxidative dearomatization of phenols. Nature Chemistry, 10(2), 119–125. https://doi.org/10.1038/nchem.2879